To evaluate the Anti-Inflammatory activity of Rhizome extract of Hedychium Coronarium by using Soxhlet Apparatus.

Abstract

Hedychium coronarium is used in traditional medicine to treat skin diseases, fever, pain and inflammation. This plant has bioactive compounds such as flavonoids, terpenoids, alkaloids, essential oils which are found in its roots and rhizomes which give it medicinal properties. The present study is aimed to evaluate experimentally the anti-inflammatory activity of Hedychium coronarium roots by phytochemical analysis and comparison with conventional anti-inflammatory drugs. Chronic inflammation is often blamed for arthritis, cardiovascular disease and many other conditions, creating a desire for safer plant-based alternatives. This research is expected to reveal significant anti-inflammatory properties in support of the traditional use of the plant and show potential of the plant as a base for herbal medicinal formulation. The study highlights the need for further studies on the active components of medicinal plants and their importance for pharmacological research. Hedychium coronarium, a medicinal plant, contains labdane diterpenes including coronarin D, which are known to have significant anti-inflammatory properties. These chemicals have been shown to inhibit inflammatory mediators such as elastase release, superoxide anion generation and COX enzymes. Coronarin D and related diterpenes are highly potent in inhibiting neutrophil mediated inflammation and oxidative stress, with a high inhibition of inflammatory markers. Their mechanisms include inhibition of reactive oxygen species, suppression of pro-inflammatory cytokines and modulation of signalling pathways such as MAPK, NF-κB.