Evolution of antiurolithiatic activity of Gardenia jasminoides

Abstract

Kidney stone disease (urolithiasis) is a common urinary tract disorder associated with significant pain, recurrence, and complications affecting renal function. The present study aims to evaluate the antiurolithiatic activity of leaf extract of Gardenia jasminoides using experimental models and to assess its potential as a natural therapeutic agent for kidney stone management. The extract was subjected to phytochemical investigation and evaluated through in vitro and/or in vivo experimental models of urolithiasis. Parameters such as crystal formation, crystal aggregation, urinary biochemical markers, renal function indicators, and histopathological changes were analyzed to determine the efficacy of the extract. The findings are expected to demonstrate the ability of Gardenia jasminoides leaf extract to inhibit calcium oxalate crystal formation, reduce stone deposition, and protect renal tissues from oxidative and inflammatory damage. The study may provide scientific evidence supporting the traditional use of the plant and suggest its potential as a safe, cost-effective, and natural alternative for the prevention and treatment of kidney stones.